An Experimental Model of Chromoblastomycosis Caused by Fonsecaea sp. Species

Methods Mol Biol. 2023;2667:129-138. doi: 10.1007/978-1-0716-3199-7_10.ABSTRACTThe experimental rodent models for the fungal disease are a handy tool for understanding host-fungus interactions. To Fonsecaea sp., one of the causative agents of chromoblastomycosis, there is an extra challenge because the animals preferably used show a spontaneous cure; so until now, there is no model to reproduce the long-term disease similar to human chronic disease. In this chapter, we described an experimental model using rats and mice with a subcutaneous route, with the checkpoints of acute-like and chronic-like lesion analysis comparable with human lesions, the fungal burden, and the lymphocytes investigation.PMID:37145281 | DOI:10.1007/978-1-0716-3199-7_10

Source: Mol Biol Cell - May 5, 2023 Category: Molecular Biology Authors: Anamelia L Bocca Isaque Medeiros Siqueira Source Type: research