Down syndrome: insights into autoimmune mechanisms

Nature Reviews Rheumatology, Published online: 05 May 2023; doi:10.1038/s41584-023-00970-0Understanding why individuals with Down syndrome are highly predisposed to autoimmunity has broad mechanistic and therapeutic implications. New work identifies novel potential mechanistic pathways driving increased autoimmunity-relevant CD11c+ B cells and provides the broadest view to date of the repertoire of autoantibodies generated in individuals with Down syndrome.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research