Fast and accurate Bayesian polygenic risk modeling with variational inference

We present VIPRS, a fast and accurate variational Bayesian method for estimating polygenic risk scores from genome-wide association study (GWAS) data. The method is shown to be robust and competitively accurate against popular baselines and scales well to dense genotype array data.

Source: The American Journal of Human Genetics - April 7, 2023 Category: Genetics & Stem Cells Authors: Shadi Zabad, Simon Gravel, Yue Li Tags: Article Source Type: research