Crystal structure of MAB_4123, a putative flavin-dependent monooxygenase from Mycobacterium abscessus

In this study, the crystal structure of the uncharacterized MAB_4123 protein from the human pathogen Mycobacterium abscessus is presented. The structure solved at high resolution displays high similarity to homologs from Rhodococcus, Paenibacillus and Pseudomonas species. In silico docking approaches suggest that MAB_4123 binds FMN and may use it as a cofactor. Structural analysis strongly suggests that MAB_4123 is a two-component flavin-dependent monooxygenase that could act as a detoxifying enzyme of organosulfur compounds in mycobacteria.

Source: Acta Crystallographica Section F - May 3, 2023 Category: Biochemistry Authors: Ung, K.L. Poussineau, C. Couston, J. Alsarraf, H.M.A.B. Blaise, M. Tags: Mycobacterium abscessus organosulfur compounds two-component flavin-dependent monooxygenases MAB_4123 research communications Source Type: research