Inhibition of a signaling modality within gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

Purpose: Adult mammals are incapable of multi-tissue regeneration and augmentation of this potential may drastically shift current therapeutic paradigms. The loss of regenerative capacity in the adult may be due to the inability to activate a pro-regenerative process, which may be in turn suppressed by the dysregulated levels of inflammatory response. IL-6 family of cytokines, which signal through glycoprotein 130 (gp130) receptor, are pleiotropic key players in inflammatory responses following injury that can promote both, regeneration and pathogenesis, depending on the perseverance of inflammatory signal.

Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: R. Shkhyan, C. Flynn, A. Sarkar, B. Van Handel, J. Tassey, H. Harn, C.-M. Chuong, N. Liu, M. Hurtig, D. Evseenko Source Type: research