Synovial invasion in the acl-t model might cause unexpected cartilage degeneration in the early stage

Purpose: Knee osteoarthritis (OA) is recognized as irreversible disease and one of the factors leading knee OA is mechanical stress. There are several kinds of mechanical stress such as compression stress and shear stress. To reveal the mechanism of developing the knee OA by mechanical stress, Anterior Cruciate Ligament transection (ACL-T) model was established; however, unexpected inflammation occurs when making this model. Recently, we succeeded to establish a novel ACL-Rupture model (Takahata et al, OAC.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research