AHNAK, Regulated by the OSM/OSMR Signaling, Involved in the Development of Primary Localized Cutaneous Amyloidosis

Primary localized cutaneous amyloidosis (PLCA) is a chronic skin disease characterized by aberrant keratinocyte differentiation, epidermal hyperproliferation, and amyloid deposits. Previously, we demonstrated OSMR loss-function mutants enhanced basal keratinocyte differentiation through the OSMR/STAT5/KLF7 signaling in PLCA patients.

Source: Journal of Dermatological Science - April 14, 2023 Category: Dermatology Authors: Huiting Liu, Biying Qiu, Huan Yang, Wen Zheng, Yingying Luo, Yadan Zhong, Ping Lu, Junyi Chen, Ying Luo, Jun Liu, Bin Yang Source Type: research