Journal club

Persistent airflow limitation in asthma: not exclusive to those with severe disease and linked with exacerbations Persistent airflow limitation (PAL) is an asthma phenotype defined as airflow obstruction that remains after the use of a β2-agonist. Past studies on PAL have included small populations and were mostly restricted to severe asthma. Kole et al (Lancet Respir Med 2023;11:55) conducted a post hoc analysis to investigate the determinants and outcomes of PAL in patients with asthma who were included in the Assessment of Small Airways Involvement in Asthma (ATLANTIS) study, a multicentric cohort with 1-year follow-up. PAL was defined by authors as a postbronchodilator FEV1/FVC less than the lower limit of normal at baseline and was identified in 33% of the 760 patients in ATLANTIS. PAL was an independent predictor of exacerbations (HR 1.73, 95% CI 1.22 to 2.48) and was associated with an earlier diagnosis, current smoking and markers...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Thorax Journal club Source Type: research