Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

Conclusions Broad consistency across MR methods may suggest causation by eosinophils (although of uncertain magnitude), yet heterogeneity necessitates caution: other important mechanisms may be responsible for the impairment of respiratory health by these eosinophil-raising variants. These results could suggest that anti-IL5 agents (designed to lower eosinophils) may be valuable in treating other respiratory conditions, including people with overlapping features of asthma and COPD.

http://thorax.bmj.com/cgi/content/short/78/5/496?rss=1

Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Guyatt, A., John, C., Williams, A. T., Shrine, N., Reeve, N. F., SpiroMeta consortium, Sayers, I., Hall, I., Wain, L. V., Sheehan, N., Dudbridge, F., Tobin, M. D., Cook, Deary, Enroth, Ewert, Gieger, Gyllensten, Harris, Hayward, Homuth, Hui, Imboden, Jame Tags: Open access, Thorax Respiratory epidemiology Source Type: research