Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex

Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC01143G, CommunicationDhrubajyoti Datta, Christopher Theile, June Qin, Kelly Wassarman , Karyn Schmidt, Tim Racie, Rachel Sigel, Yongfeng Jiang, Maja M. Janas, Martin Egli, Muthiah Manoharan To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA induced silencing complex (RISC). We have previously demonstrated that a 5 ʹ-morpholino-modified nucleotide at... The content of this RSS Feed (c) The Royal Society of Chemistry

http://pubs.rsc.org/en/Content/ArticleLanding/2023/CC/D3CC01143G

Source: RSC - Chem. Commun. latest articles - April 10, 2023 Category: Chemistry Authors: Dhrubajyoti Datta Source Type: research

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