CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

Abstract
Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of β- and meso-substituted and 1,2,3-triazole-fused porphyrin conjugates. All of the porphyrin conjugates discussed here are synthesized via a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction between an azide and a terminal alkyne, also popular as "click reaction" or CuAAC reaction. Moreover, the 1,2,3-triazole ring also serves as a spacer and an electron transfer bridge between the porphyrin and the attached chromophores. In order to provide a critical overview of the synthesis and properties of various porphyrin-triazole hybrids, this review will discuss some of the key reactions involved in the preparation of triazole-linked porphyrin conjugates.

Beilstein J. Org. Chem. 2023, 19, 349–379. doi:10.3762/bjoc.19.29

Source: Beilstein Journal of Organic Chemistry - March 22, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: azide – alkyne click chemistry CuAAC 1,3-dipolar cycloaddition porphyrin 1,2,3-triazole Review Source Type: research