A founder UMOD variant is a common cause of hereditary nephropathy in the British population

Conclusion
Our data confirm a likely founder UMOD variant with a wide geographical distribution within the UK. It should be suspected in cases of unexplained familial nephropathy presenting in patients of white British ancestry.

Source: Journal of Medical Genetics - March 20, 2023 Category: Genetics & Stem Cells Authors: Valluru, M. K., Chung, N. K., Gilchrist, M., Butland, L., Cook, J., Takou, A., Dixit, A., Weedon, M. N., Ong, A. C. M., The Genomics England Research Consortium, Ambrose, Arumugam, Bevers, Bleda, Boardman-Pretty, Boustred, Brittain, Caulfield, Chan, Elgar Tags: Open access Population genetics Source Type: research