Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases

Nature Reviews Endocrinology, Published online: 17 March 2023; doi:10.1038/s41574-023-00817-4This Review highlights mechanisms of glucagon secretion from pancreatic α-cells, including paracrine actions in islets and α-cell–β-cell crosstalk. Dysregulated glucagon secretion in metabolic diseases is also considered and the clinical potential of targeting glucagon is discussed.

Source: Nature Reviews Endocrinology - March 17, 2023 Category: Endocrinology Authors: Sofie H ædersdal Andreas Andersen Filip K. Knop Tina Vilsb øll Source Type: research