Over ‐expression of USP15/MMP3 predict poor prognosis and promote growth, migration in non-small cell lung cancer cells

Lung cancer has been one of the main causes of cancer-related mortality worldwide over the past few decades [1]. In total, ∼80% of the patients with lung cancer are histopathologically diagnosed with the non-small cell lung cancer (NSCLC) subtype [2,3]. Although 30-40% of the patients exhibit good responses to cytotoxic therapy initially, most, if not all, of the patients will eventually relapse during or after treatm ent [4–6]. Dysregulation of oncogene and tumor suppressor gene expression contributes to the progression of NSCLC [7–10].

Source: Cancer Genetics and Cytogenetics - January 6, 2023 Category: Genetics & Stem Cells Authors: Weiwei Chen, Daguang Ni, Hailin Zhang, Xia Li, Youqin Jiang, Jixiang Wu, Yan Gu, Mingcheng Gao, Woda Shi, Jianxiang Song, Wenyu Shi Tags: Original Article Source Type: research