Leukocytoclastic Vasculitis Associated with Adalimumab Therapy for Crohn ’s Disease

We report a 22-year-old man with new onset of a pustular rash on his bilateral upper and lower extremities while on adalimumab therapy for Crohn’s disease. Skin biopsy of the affected area showed perivascular extravasation of erythrocytes, neutrophils, eosinophils and vascular damage s urrounding blood vessels associated with fibrin, consistent with LCV. Patient was treated with topical steroids and subsequently transitioned to ustekinumab therapy with follow-up colonoscopy showing minimal active disease. Our report highlights the association of a unique dermatologic autoimmune ma nifestation with TNF-targeted therapy in a patient with Crohn’s disease.Case Rep Gastroenterol 2023;17:143 –147
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research