Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin

Bleomycin hydrolase (BH), which is expressed in the stratum granulosum and lower stratum corneum (SC), is involved in final filaggrin degradation. Furthermore, BH plays an essential role in producing free amino acids, which constitute the majority of natural moisturizing factors (NMF). However, the effects of BH expression and protease activity on human skin aging remain unclear.

Source: Journal of Dermatological Science - March 5, 2023 Category: Dermatology Authors: Munehiro Tsurumachi, Yayoi Kamata, Mitsutoshi Tominaga, Junko Ishikawa, Tomoki Hideshima, Eri Shimizu, Takahide Kaneko, Yasushi Suga, Kenji Takamori Source Type: research