Wessely corneal ring phenomenon: An unsolved pathophysiological dilemma.

The cornea is a densely innervated, avascular tissue showing exceptional inflammatory and immune responses. The cornea is a site of lymphangiogenic and angiogenic privilege devoid of blood and lymphatic vessels that limits the entry of inflammatory cells from the adjacent and highly immunoreactive conjunctiva. Immunological and anatomical differences between the central and peripheral cornea are also necessary to sustain passive immune privilege. The lower density of antigen-presenting cells in the central cornea and the 5:1 peripheral-to-central corneal ratio of C1 are 2 main features conferring passive immune privilege.

Source: Survey of Ophthalmology - March 4, 2023 Category: Opthalmology Authors: Raul E. Ruiz-Lozano, Marcelo Salan-Gomez, Alejandro Rodriguez-Garcia, Manuel E. Quiroga-Garza, Eugenia M. Ramos-D ávila, Victor L. Perez, Nadim S. Azar, Jesus Merayo-Lloves, Julio C. Hernandez-Camarena, Jorge E. Valdez-García Tags: Review article Source Type: research