Folate metabolism negatively regulates OAS-mediated antiviral innate immunity via ADAR3/endogenous dsRNA pathway

Folate (FA) is an essential cofactor in the one-carbon (1C) metabolic pathway and participates in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. FA metabolism has been reported to play an important role in viral replications; however, the roles of FA metabolism in the antiviral innate immune response are unclear.

Source: Metabolism - Clinical and Experimental - February 21, 2023 Category: Biomedical Science Authors: Jing Wu, Qiao You, Ruining Lyu, Yajie Qian, Hongji Tao, Fang Zhang, Yurong Cai, Na Jiang, Nan Zheng, Deyan Chen, Zhiwei Wu Source Type: research