HIV rapidly targets a diverse pool of CD4+ T  cells to establish productive and latent infections

The early cellular targets of HIV and the mechanisms of viral dissemination in humans remain elusive. Gantner et  al. demonstrate that the early targets of HIV rapidly change during acute infection and differ between blood and lymph nodes. They also observe that latent and genetically intact proviruses persisting during therapy are archived from the earliest stages of acute infection.

Source: Immunity - February 17, 2023 Category: Allergy & Immunology Authors: Pierre Gantner, Supranee Buranapraditkun, Am élie Pagliuzza, Caroline Dufour, Marion Pardons, Julie L. Mitchell, Eugène Kroon, Carlo Sacdalan, Nicha Tulmethakaan, Suteeraporn Pinyakorn, Merlin L. Robb, Nittaya Phanuphak, Jintanat Ananworanich, Denise Hs Tags: Article Source Type: research