Integrating Forward and Reverse Translation in PBPK Modeling to Predict Food Effect on Oral Absorption of Weakly Basic Drugs

ConclusionThe two examples presented in this paper show how middle-out modeling approaches can be used to predict the magnitude and direction of food effects provided the model is verified on fasted state PK data.Graphical Abstract
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research