Archaic humans have contributed to large-scale variation in modern human T  cell receptor genes

T cells are critical for immunological responses to pathogens and malignancies; yet, knowledge of variation in expressed human TCR germline genes is limited. Corcoran et  al. reveal large TCR allelic variation, doubling the number of validated alleles, showing that many are population-specific and revealing several that originate from human-Neanderthal interbreeding.

Source: Immunity - February 15, 2023 Category: Allergy & Immunology Authors: Martin Corcoran, Mark Chernyshev, Marco Mandolesi, Sanjana Narang, Mateusz Kaduk, Kewei Ye, Christopher Sundling, Anna F ärnert, Taras Kreslavsky, Carolina Bernhardsson, Maximilian Larena, Mattias Jakobsson, Gunilla B. Karlsson Hedestam Tags: Article Source Type: research