Cross-sectional audit assessing the quality of dried bloodspot specimens received by UK metabolic biochemistry laboratories for the biochemical monitoring of individuals with Phenylketonuria

CONCLUSIONS: There is significant variability in the quality of patient-collected DBS specimens. If unacceptable specimens are not rejected, imprecise/inaccurate results will be used in clinical decision making. Using annual workload data for England, this equates to 12,410 incorrect results. Individuals and parents/carers should receive ongoing training in blood collection technique to ensure use of evidence-based acceptability criteria does not cause undue distress from increased sample rejection rates.PMID:36762708 | DOI:10.1177/00045632231156035

Source: Clinical Biochemistry - February 10, 2023 Category: Biochemistry Authors: Sarah L Hogg Rachel S Carling Nathan Wp Cantley Gillian Hamilton Philippa Goddard Helen Aitkenhead Robert Barski Catherine Collingwood Stuart J Moat Helena J Kemp Source Type: research