SOHO State of the Art Updates and Next Questions | Infections in Chronic Lymphocytic Leukemia Patients: Risks and Management

Although chronic lymphocytic leukemia (CLL) is a malignancy characterized by accumulation of tumor cells in the blood, bone marrow, lymph nodes and secondary lymphoid tissues, the hallmark of the disease and the major cause of death for patients with CLL is actually immune dysfunction and associated infections. Despite improvement in treatment based on combination chemoimmunotherapy and targeted treatment with BTK and BCL-2 inhibitors leading to longer overall survival for patients with CLL, the mortality due to infections have not improved over the last four decades.

Source: Clinical Lymphoma, Myeloma and Leukemia - February 10, 2023 Category: Hematology Authors: Ernesto Gargiulo, Eduardo Flavio Oliveira Ribeiro, Carsten U. Niemann Tags: Review Article Source Type: research