Extracorporeal Shock Wave Therapy Improves Nontraumatic Knee Contracture in a Rat Model

CONCLUSION: The findings suggest that ESWT improved joint contracture by inhibiting the TGF-β1/SMADs signaling pathway in rats.CLINICAL RELEVANCE: This work suggests ESWT may be worth exploring in preliminary research in humans to determine whether it may be a treatment option for patients with nontraumatic knee contractures. If the mechanism of ESWT can be confirmed in humans, ESWT might be a therapy for diseases involved in the TGF-β1/SMADs signaling pathway, such as hypertroic scarring and scleroderma.PMID:36724201 | DOI:10.1097/CORR.0000000000002559
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Source Type: research