Tissue-specific abundance of interferon-gamma drives regulatory T  cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

How tissue-specific mechanisms shape anti-tumor immunity remains poorly understood. Zagorulya et  al. reveal that lung lymph node (LN)-specific abundance of interferon-gamma induces suppressive Th1-like effector regulatory T (Treg) cells. These effector Treg cells interact with type 1 conventional dendritic cells and restrain priming of cytotoxic T cell responses against lung cancer.

Source: Immunity - February 2, 2023 Category: Allergy & Immunology Authors: Maria Zagorulya, Leon Yim, Duncan M. Morgan, Austin Edwards, Elen Torres-Mejia, Noor Momin, Chloe V. McCreery, Izabella L. Zamora, Brendan L. Horton, James G. Fox, K. Dane Wittrup, J. Christopher Love, Stefani Spranger Tags: Article Source Type: research