Heightened Pro ‐inflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients with Antibiotic‐Refractory Lyme Arthritis
ConclusionPatients with antibiotic-responsive LA hadBb-IgG1 antibodies with more balanced pro-inflammatory/anti-inflammatory glycan profiles, whereas patients with antibiotic-refractory LA hadBb-IgG1 antibodies with maximal, minimally opposed, pro-inflammatory glycan profiles. Among patients with antibiotic refractory LA, antibodies with this unbalanced inflammatory glycan profile may play a role in sustaining maladaptive joint inflammation.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Jurgen T. Sanes, Catherine E. Costello, Allen C. Steere Tags: Full Length Source Type: research
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