Point-of-Care Testing of Enzyme Polymorphisms for Predicting Hypnotizability and Postoperative Pain

Hypnotizability is a stable trait that moderates the benefit of hypnosis for treating pain, but limited availability of hypnotizability testing deters widespread use of hypnosis. Inexpensive genotyping of four single-nucleotide polymorphisms in the catechol-o-methyltransferase (COMT) gene was performed using giant magnetoresistive biosensors to determine if hypnotizable individuals can be identified for targeted hypnosis referrals. For individuals with the proposed optimal COMT diplotypes, 89.5% score highly on the Hypnotic Induction Profile (odds ratio,  6.12; 95% CI, 1.26–28.75), which identified 40.5% of the treatable population.

Source: Journal of Molecular Diagnostics - January 23, 2023 Category: Pathology Authors: Dana L. Cortade, Jessie Markovits, David Spiegel, Shan X. Wang Tags: Regular article Source Type: research