G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells

The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2 –7 (EGFRvIII) being amongst the most common genomic mutations. E...

Source: Radiation Oncology - January 29, 2023 Category: Cancer & Oncology Authors: Meryem H. Cetin, Thorsten Rieckmann, Konstantin Hoffer, Britta Riepen, Sabrina Christiansen, Fruzsina Gatzemeier, Simon Feyerabend, Melanie Schoof, Ulrich Sch üller, Cordula Petersen, Martin Mynarek, Kai Rothkamm, Malte Kriegs and Nina Struve Tags: Research Source Type: research