Accelerated Phase of MPN: What It Is and What to Do About It

Progression of Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) to the accelerated phase (AP) or blast phase (BP) is associated with poor outcomes. As our understanding of the molecular drivers of MPN progression has grown, there has been increasing investigation into the use of novel targeted approaches in the treatment of these diseases. In this review we summarize the clinical and molecular risk factors for progression to MPN-AP/BP followed by discussion of treatment approach.

Source: Clinical Lymphoma, Myeloma and Leukemia - January 25, 2023 Category: Hematology Authors: Anand A. Patel, Olatoyosi Odenike Tags: Review Article Source Type: research