Point of care testing of enzyme polymorphisms for predicting hypnotizability and postoperative pain

Hypnotizability is a stable trait that moderates the benefit of hypnosis for treating pain, but limited availability of hypnotizability testing deters widespread use of hypnosis. Inexpensive genotyping of 4 single nucleotide polymorphisms in the catechol-o-methyltransferase (COMT) gene was performed using giant magnetoresistive biosensors to determine if hypnotizable individuals can be identified for targeted hypnosis referrals. For individuals with the proposed ‘optimal’ COMT diplotypes, 89.5% score highly on the Hypnotic Induction Profile (OR = 6.12, 95%CI = 1.26-28.75), which identified 40.5% of the treatable population.

Source: Journal of Molecular Diagnostics - January 23, 2023 Category: Pathology Authors: Dana L. Cortade, Jessie Markovits, David Spiegel, Shan X. Wang Tags: Regular Article Source Type: research