Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid

Nature Protocols, Published online: 18 January 2023; doi:10.1038/s41596-022-00787-3The amplification of misfolded alpha-synuclein aggregates in vitro can be used for the detection, via fluorescent dyes, of pathologic amyloids in cerebrospinal fluid samples from patients affected by Parkinson’s disease, dementia with Lewy bodies or multiple-system atrophy.

Source: Nature Protocols - January 18, 2023 Category: Biomedical Science Authors: Luis Concha-Marambio Sandra Pritzkow Mohammad Shahnawaz Carly M. Farris Claudio Soto Source Type: research