Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling

In conclusion, the inhibition of osteocalcin on muscle cell aging is accompanied by the induction of IL-6-STAT3-dependent autophagy, indicating osteocalcin might be a promising therapeutic candidate for aging-related myopathies.PMID:36621698 | DOI:10.1016/j.exger.2023.112082

Source: Experimental Gerontology - January 9, 2023 Category: Geriatrics Authors: Pengying Gu Daidi Tao Yuanyuan Xu Qian Yang Tingting Bai Shilian Hu Xingyuan Yang Source Type: research