Dose-Dependent Association Between Sarcopenia and Moderate-to-Severe Thoracic Vertebral Fragility Fracture in Older Adults

Introduction Sarcopenia and vertebral fracture affect a large number of older adults and can be debilitating. However, the correlation between sarcopenia and vertebral fracture has not been well studied. Thus, this study investigates the correlation between vertebral fragility fracture and the severity of sarcopenia. Method This cross-sectional study included 300 community-dwelling older adults with risk higher than 10-year probability of 3% for a hip fracture and 20% for a major osteoporotic fracture by FRAX score. Sarcopenia was defined according to the Asian Working Group for Sarcopenia consensus. Bone mineral density (BMD) was classified into normal or abnormal groups (T-score ≤ -1.0) according to WHO criteria. Vertebral fracture was graded mild, moderate, and severe by standardized semi-quantitative method. The association between sarcopenia and vertebral fragility fracture was investigated using a logistic regression model adjusted for confounding factors. Results Com pared with the normal BMD group, the abnormal BMD group had a significantly higher prevalence of sarcopenia (7.4% vs. 26.6%, p
Source: Gerontology - Category: Geriatrics Source Type: research