Comparison of the mathematical equation and trapezoidal approach for 24  h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care setting

Correlation between calculated AUC (mg ·h/L) by Method 1 (trapezoidal method) and Method 2 (equation method); AUC-equation A method (▲), AUC-equation B method (○) classification by pair of serum vancomycin concentrations were brought to determine AUC from equation A and B. (C2: vancomycin concentration at the end of infusion,C2.5: vancomycin concentration at 2.5  h after starting the infusion,C3: vancomycin concentration at 3  h after starting the infusion andCT: vancomycin concentration before the true trough concentration 1  h,R2, the coefficient of determination). AbstractThe current recommendation for therapeutic monitoring of vancomycin has recently suggested AUC-guided dosing in patients with serious methicillin-resistantStaphylococcus aureus infections. The study objective was to evaluate mathematical equations and trapezoidal methods for calculating the 24  h area under the plasma vancomycin concentration-time curve (AUC24). The analysis of plasma vancomycin concentrations was performed in 20 adult patients treated with intravenous vancomycin. For each patient, AUC24 was estimated using two methods including, equation and trapezoidal calculation. Th e AUC24 from two methods was analyzed for correlation. The correlation between the equation and trapezoidal methods was strong. The coefficient of determination (R2) values was greater than .99. The two plasma vancomycin concentrations to achieve the highest correlation were concentration at 2.5 to 3  h after...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research