Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

Although immune checkpoint blockade (ICB) influence on T  cells is well known, its impact on antibodies is less understood. Wu et al. show how ICB-elicited sialylation of IgG suppresses DC-SIGN-expressing macrophages in human hepatocellular carcinoma. Impeding IgG sialylation augments macrophage IFN-I responses and antitumorigenic T cell immunity durin g immunotherapy.

Source: Immunity - December 22, 2022 Category: Allergy & Immunology Authors: Rui-Qi Wu, Xiang-Ming Lao, Dong-Ping Chen, Hongqiang Qin, Ming Mu, Wen-Jie Cao, Jia Deng, Chao-Chao Wan, Wan-Yu Zhan, Jun-Cheng Wang, Li Xu, Min-Shan Chen, Qiang Gao, Limin Zheng, Yuan Wei, Dong-Ming Kuang Tags: Article Source Type: research