Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells

Heme is the principal component of hemoglobin that carries oxygen molecules that are abundantly produced during the maturation of erythroblasts into red blood cells (RBCs). Half of the steps of heme synthesis are catalyzed in mitochondria [1]. In contrast to this dependence on mitochondria for heme synthesis, erythroblasts undergo enucleation and clearance of cytoplasmic components, including mitochondria, which are potential consumers of oxygen and can generate deleterious reactive oxygen species (ROS).

Source: Experimental Hematology - December 5, 2022 Category: Hematology Authors: Masatoshi Ikeda, Hiroki Kato, Hiroki Shima, Mitsuyo Matsumoto, Eijiro Furukawa, Yan Yan, Ruiqi Liao, Jian Xu, Akihiko Muto, Tohru Fujiwara, Hideo Harigae, Emery H. Bresnick, Kazuhiko Igarashi Tags: Article Source Type: research