Kavain ablates the radio-resistance of IDH-wildtype glioblastoma by targeting LITAF/NF- κB pathway

ConclusionIn mechanism, our results indicated that 1) the elevation of LITAF in GBM cells activates the NF- κB pathway to promote mesenchymal transition, and 2) kavain disturbs STAT6B/LITAF protein interaction and then expels LITAF from the nucleus. Therefore, we consider that kavain may be a potential candidate to develop an irradiation therapy adjuvant for GBM.

Source: Cellular Oncology - December 5, 2022 Category: Cancer & Oncology Source Type: research