Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations

ConclusionsWe found that engineered mAbs require specially optimized exponents to accurately predict pharmacokinetic parameters and plasma concentration –time profiles after IV injections in humans based on cynomolgus monkey data. This optimized approach can contribute to a more accurate prediction of human pharmacokinetics in the development of engineered mAbs.
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research