Synthetic study toward the diterpenoid aberrarone

Abstract
An approach to aberrarone, an antimalarial diterpenoid natural product with tetracyclic skeleton is reported. Key to the stereoselective preparation of the 6-5-5 tricyclic skeleton includes the mediation of Nagata reagent for constructing the C1 all-carbon quaternary centers and gold-catalyzed cyclopentenone synthesis through C–H insertion.

Beilstein J. Org. Chem. 2022, 18, 1625–1628. doi:10.3762/bjoc.18.173

Source: Beilstein Journal of Organic Chemistry - November 30, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: aberrarone C – H insertion gold Pauson Khand total synthesis Letter Source Type: research