11. The complex nature of variant interactions in cancer requires updates to variant interpretation resources

CIViC, the Clinical Interpretation of Variants in Cancer knowledgebase (www.civicdb.org), has provided structured data and an open-access curation interface to enable scientists and other community stakeholders to curate variant information from published literature since 2014. Since then, CIViC has continued to evolve to incorporate new community guidelines and user feedback. CIViC has been embraced by the community with>300 contributors submitting content that represents>3100 publications,>450 genes, and>3000 variants, and become the official knowledgebase supporting somatic cancer variant curation efforts for ClinGen.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Kilannin Krysiak, Susanna Kiwala, Adam C. Coffman, Joshua F. McMichael, Arpad M. Danos, Jason Saliba, Cameron J. Grisdale, Jake Lever, Lana Sheta, Shruti Rao, Alex H. Wagner, Malachi Griffith, Obi L. Griffith Source Type: research