61. Clinical whole exome/whole transcriptome analysis detects clinically relevant structural alterations in Multiple Myeloma

Chromosomal copy number alterations (CNAs) and structural rearrangements (SR) are a key part of risk stratification and management of patients with MM. We developed a clinical paired tumor/normal WES/WTS assay that detects CNAs at one-copy difference from focal to whole genome, and gene fusion at 20% and 10% limit of detection, respectively.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Maria Nieves Calvo, Sean Caruthers, Joseph Tripodi, Jane Houldsworth, Marc Fink, Scott Newman, Rong Chen, Wanying Zhang, Liu Liu, Yong Shi, Tomi Jun, Ken Onel, William Oh, Lisa Edelmann, Eric Schadt, Michael Rossi, Feras Hantash, Hussam Al-Kateb Source Type: research