67. Long noncoding RNAs encoding peptides in cancer

Long noncoding RNAs (lncRNAs) have biological and clinical significance in cancer, but their mechanisms remain underexplored. One emerging mechanism includes translation of small peptides with reported roles in cancer progression from annotated lncRNAs, highlighting the need for efficient mechanism prediction and validation of specific candidates. Through comprehensive proteogenomic analysis, we found several additional well-known oncogenic lncRNAs and uncharacterized, cancer type-specific lncRNAs with support for peptide coding capabilities.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Emily Coonrod, Ghofran Othoum, Andrew Nickless, Jin Zhang, Matthew Inkman, Sidi Zhao, Ha Dang, Jace Webster, Emily Rozycki, Sherron Fontes, Nicole White, Christopher Maher Source Type: research