71. Genetic predisposition to hematopoietic neoplasms: Single-site experience

Hematopoietic neoplasm testing generally involves sequencing of recurrent genes found to be mutated in these cancers. A few genes are detected in both germline and somatic-derived malignancies; however, ANKRD26 and DDX41 are previously only associated with germline predisposition and not detected in somatic-derived cancers, and often not included on sequencing panels. Our institution utilizes a panel including both genes and the findings have underscored the value of testing for these alterations.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research