84. Benefits of integrating an open-source knowledgebase in a precision oncology workflow

Next-generation sequencing is revolutionizing precision oncology, but vast amounts of sequence data must be processed and mined to reveal clinically relevant alterations that can inform patient care. The Personalized OncoGenomics (POG) program at BC Cancer utilizes whole genome and transcriptome analysis, providing a comprehensive view of advanced cancer patient tumours. This analysis relies on curated clinical knowledgebases linking cancer variants and their clinical relevance, but the breadth and utility of these can be limited by proprietary access or limited coverage.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Cameron Grisdale, Erin Pleasance, Caralyn Reisle, Laura Williamson, Kilannin Krysiak, Jason Saliba, Arpad Danos, Adam Coffman, Susanna Kiwala, Joshua McMichael, Malachi Griffith, Obi L. Griffith, Steven Jones Source Type: research