A study of the DIBAL-promoted selective debenzylation of α -cyclodextrin protected with two different benzyl groups

Abstract
An α-cyclodextrin protected with 2,4-dichlorobenzyl groups on the primary alcohols and ordinary benzyl groups on the secondary alcohols was prepared and subjected to DIBAL (diisobutylaluminum hydride)-promoted selective debenzylation. Debenzylation proceeded by first removing two dichlorobenzyl groups from the 6A,D positions and then removing one or two benzyl groups from the 3A,D positions.

Beilstein J. Org. Chem. 2022, 18, 1553–1559. doi:10.3762/bjoc.18.165

Source: Beilstein Journal of Organic Chemistry - November 17, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: aluminum hydrides cyclodextrin debenzylation 2,4-dichlorobenzyl selective Full Research Paper Source Type: research