Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate

ConclusionHistamine produced by HDC-induction mainly in infiltrated neutrophils stimulates H4Rs, leading to augmented Ale  + LPS-induced ear-swelling via MCP-1 production by MCs. Since MCP-1 is produced by other cells, too, the contribution of MCs and their H4Rs to augmented ear-swelling is partial. In the later phase of the swelling, MCs may be anti-inflammatory via IL-10 production.

Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research