New Metabolites of Rhodiola rosea I. Glycosides of Herbacetin and Gossypetin

New O-glycosides of herbacetin and gossypetin (1–6) and eight known compounds were isolated from leaves ofRhodiola rosea L. [Sedum roseum (L.) Scop., Crassulaceae]. According to UV, IR, and NMR spectroscopic and mass spectrometric data, the isolated compounds were herbacetin-3-O-(3 ′′ -O-malonyl)-β-Dglucopyranoside-7-O-β-D-glucopyranoside-8-O-β-D-glucuronopyranoside (rhodirosin A,1), herbacetin- 3-O-(3 ′′,4′′-di-O-acetyl)-β-D-glucopyranoside-8-O-β-D-glucuronopyranoside (rhodirosin B,2), gossypetin- 8-O-(2 ′′-O-malonyl)-β-D-glucuronopyranoside (rhodirosin C,3), gossypetin-8-O-(2 ′′-O-acetyl)-β-Dglucuronopyranoside (rhodirosin D,4), herbacetin-8-O-(2 ′′-O-malonyl)-β-D-glucuronopyranoside (rhodirosin E,5), and herbacetin-8-O-(2 ′′ -O-acetyl)-β-D-glucuronopyranoside (rhodirosin F,6). Flavonoids3 and4 possessed the highest antiradical activity and inhibited the activity ofα-amylase.

Source: Chemistry of Natural Compounds - November 10, 2022 Category: Chemistry Source Type: research