HLA Typing by Next-Generation Sequencing

The HLA region on chromosome 6p21 covers more than 224 annotated genes, covering a span of more than 3.6 megabases. Although that may seem large, it comprises less than 0.15% of the whole human genome1. This region has been one of the most studied regions of the human genome since its discovery2 and contains a plethora of genes that are crucial for immune cell function and regulation3,4. The major histocompatibility complex (MHC) class I molecules, encoded by HLA-A, HLA-B, and HLA-C, are used by nearly all cells in the human body to express endogenous proteins on their surface for immune cell surveillance5.
Source: Clinics in Laboratory Medicine - Category: Laboratory Medicine Authors: Source Type: research