Blood Group Genotyping

Red blood cell (RBC) antigens are inherited, intrinsic or adsorbed surface structures provoking specific humoral immune response. Historically, serologic —antibody-based and relatively unchanged since the early 20th century—assays imperfectly defined these antigens, at times hindering accurate phenotyping and compatible RBC transfusion and solid organ transplantation. Single-nucleotide variants (SNV), and less frequently structural variants, copy number variants or regulatory region variants encode RBC antigens.
Source: Clinics in Laboratory Medicine - Category: Laboratory Medicine Authors: Source Type: research