Advanced Glycation End Products, Bone Health, and Diabetes Mellitus

Exp Clin Endocrinol Diabetes 2022; 130: 671-677 DOI: 10.1055/a-1861-2388Advanced glycation end products (AGEs), the compounds resulting from the
non-enzymatic glycosylation between reducing sugars and proteins, are derived
from food or produced de novo. Over time, more and more endogenous and
exogenous AGEs accumulate in various organs such as the liver, kidneys, muscle,
and bone, threatening human health. Among these organs, bone is most widely
reported. AGEs accumulating in bone reduce bone strength by participating in
bone structure formation and breaking bone homeostasis by binding their
receptors to alter the proliferation, differentiation, and apoptosis of cells
involved in bone remodeling. In this review, we summarize the research about the
effects of AGEs on bone health and highlight their associations with bone health
in diabetes patients to provide some clues toward the discovery of new treatment
and prevention strategies for bone-related diseases caused by AGEs. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Experimental and Clinical Endocrinology and Diabetes - October 18, 2022 Category: Endocrinology Authors: Jiang, Jingjing Zhao, Changyu Han, Tingting Shan, Hongyan Cui, Guiyou Li, Songnan Xie, Zhongwen Wang, Jun Tags: Review Source Type: research